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Image Search Results
Journal: PLoS ONE
Article Title: Comparative mRNA and miRNA transcriptome analysis of a mouse model of IGFIR-driven lung cancer
doi: 10.1371/journal.pone.0206948
Figure Lengend Snippet: (A) Schematic of doxycycline inducible expression of IGFIR in the mouse lung via the SPC promoter. (B) Unsupervised hierarchical clustering dendrogram of RNA-Seq data from tumor (T, red) and non-transgenic normal lung (N, grey) samples. (C) Volcano plot of log2 fold changes and differential expression p values between tumor and normal lung tissue. (D) Pie chart illustrating percentage of genes up and down-regulated in IGFIR-driven tumors. (E) Dot plots of endogenous murine Igf1r (padj = 5.71E-11) and human IGFIR transgene (padj = 5.65E-249) mRNA expression following mapping to a hybrid genome. (F) Heatmap showing differential expression of markers of AT2 and Club cells as well as subtypes of non-small cell lung cancer. ADC, adenocarcinoma, SCC, squamous cell carcinoma, mADC, mucinous adenocarcinoma. Adjusted p-values for (C) and (E) were obtained from DESeq2.
Article Snippet: To further enrich for tumor cells, a
Techniques: Expressing, RNA Sequencing, Transgenic Assay, Quantitative Proteomics
Journal: Nature communications
Article Title: FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.
doi: 10.1038/s41467-019-09418-0
Figure Lengend Snippet: Fig. 8 Schematic model of insulin regulation of FoxK1/K2 and FoxOs in cellular function. The FoxK Forkhead transcription factors translocate from the cytoplasm to nucleus reciprocally to the translocation of FoxO1. FoxK translocation to the nucleus is dependent on the Akt-mTOR pathway, while its localization to the cytoplasm in the basal state is dependent on GSK3. Once in the nucleus, FoxKs play important roles in regulation of genes, fatty acid oxidation, mitochondrial biogenesis, cell proliferation and survival. Where other unknown proteins (named here X) are in the FoxK and IR/IGF1R protein- protein complexes remains to be determined
Article Snippet: Mouse IR (MC224356) and
Techniques: Cell Function Assay, Translocation Assay